Tag Archives: psilocybin

US Govt. Designates Psilocybin As Breakthrough Treatment

Under a new designation by the US Food and Drug Administration (FDA), psilocybin – a hallucinogenic chemical found in psychedelic mushrooms – is now considered a “breakthrough treatment” for major depressive disorder (MDD), putting it on the “fast track” for future clinical studies.

Breakthrough Therapy designation grants a potential treatment priority review by the FDA to further understanding of how it may treat certain disorders and illnesses. The designation was granted after a request from the Usona Institute, a nonprofit medical research group conducting research on psilocybin, in recognition that there is an unmet medical need that may be fulfilled through psilocybin’s potential to improve existing therapies.

Characterized by a persistent feeling of sadness or loss of interest, MDD is a mood disorder that affects how a person may think, feel, and behave – all of which can trickle into everyday activities, according to the Mayo Clinic. MDD impacts more than 16 million people in the US and is the leading cause of disability in those between the ages of 15 and 44, according to the Anxiety and Depression Association of America. It is estimated that 322 million people globally live with some type of depression.

Previous studies have shown that magic mushrooms can ease severe depression and may “reset” the brains of people with depression without the emotional numbing associated with some traditional antidepressants. It is unclear how exactly the chemical compound may treat depression, but a study from the Beckley Foundation suggests that psilocybin may reactivate or connect certain regions of the brain and their neural capacity.

“The results from previous studies clearly demonstrate the remarkable potential for psilocybin as a treatment in MDD patients, which Usona is now seeking to confirm in its own clinical trials. What is truly groundbreaking is FDA’s rightful acknowledgement that MDD, not just the much smaller treatment-resistant depression population, represents an unmet medical need and that the available data suggest that psilocybin may offer a substantial clinical improvement over existing therapies,” said Charles Raison, MD, director of Clinical and Translational Research at Usona, in a statement.

“Given that there is so much complexity with psilocybin and that Usona is charting new ground, these interactions will ensure that Usona and the FDA are aligned in approaching the development program with acceptable best practices,” he added.

Usona is currently moving into its Phase 2 clinical trial PSIL201 with 80 study participants across seven US study sites, two of which are currently recruiting while the others aim to be active at the beginning of the new year.

BARRUS/Shutterstock

[H/T: Live Science]

Decriminalization of Mushrooms in 2018

California voters could decide whether the state should decriminalize the use of hallucinogenic mushrooms by adults in 2018. A ballot measure was filed Friday with the state Attorney General’s office.
The measure would exempt adults 21 and older from penalties of possessing, selling, transporting, or cultivating psilocybins.

At least 365,880 valid signatures are needed to place the measure on the 2018 statewide ballot.

Kevin Saunders, a mayoral candidate in the town of Marina, near Monterey, is behind the push.

Saunders said using mushrooms helped him stop using heroin 15 years ago.

“I think we’re seeing something that could literally heal our brothers and sisters,” he said. “We’re talking about real cutting-edge stuff.”

Saunders said he hopes voters will be mature and have a serious, robust conversation about the use of mushrooms.

“It’s a natural progression from marijuana legalization,” he said. “I think that we are having an opportunity to lead the discussion.”

Californians voted to legalize recreational marijuana use in November through Proposition 64.

Psilocybin is considered a Schedule I drug by the California Controlled Substances Act and the U.S. Drug Enforcement Agency.

These drugs have no accepted medical use and a high potential for dependence and abuse, according to the DEA. Heroin, LSD, and marijuana are in the same category.

Two 2016 studies found a dosage of psilocybin helped ease anxiety and depression for some cancer patients.
Source – LATIMES

Johns Hopkins Psilocybin Project

 

Made for Purdue University Psychoactive Substances Research Collection: https://www.youtube.com/user/Psychede…

Roland R. Griffiths, Ph.D., is Professor in the Departments of Psychiatry and Neurosciences at the Johns Hopkins University School of Medicine. His principal research focus in both clinical and preclinical laboratories has been on the behavioral and subjective effects of mood-altering drugs. His research has been largely supported by grants from the National Institute on Health and he is author of over 300 journal articles and book chapters. He has been a consultant to the National Institutes of Health, and to numerous pharmaceutical companies in the development of new psychotropic drugs. He is also currently a member of the Expert Advisory Panel on Drug Dependence for the World Health Organization. He has an interest in meditation and is the lead investigator of the psilocybin research initiative at Johns Hopkins, which includes studies of psilocybin occasioned mystical experience in healthy volunteers and cancer patients, and a pilot study of psilocybin-facilitated smoking cessation. Roland Griffiths. Alicia Danforth. Charles Grob. Matthew Johnson. Albert Garcia-Romeu. Tony Bossis. Stephen Ross. David Nichols.

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My Journey Through The Magic Mushroom Portal

The original Notes to what I experienced below…. a bit more detailed I think.

June 12 2013

InFocus247- Journey Mental trip saw one of the most beautiful train stations in the middle of the jungle the train tracks were gold or the reflection of the tracks looked gold from the sun reflecting off of them, After going through a combination of  lights and shapes it seemed to be a transitional stage kaleidoscope like effect going from place to place soon after i was climbing up what seemed to be a tree but it was very tall it lead into the sky it was so tall. Once i climbed high enough i saw i was able to see a very beautiful river/ocean the feeling gave me a rushing sense of happiness and I felt my heart expanding it made me take a deep breath it felt as if I were there. The next sensation or urge I felt was to jump, so  i jumped off  of the tree into what seemed like a sky dive  i remember  two entities flying after me I felt a brief thought of fear as if I weren’t supposed to jump but water was below so I reassured my self I was ok but not only that… I can fly  so I began flying I flew under two  bridges and then remember soon after standing by some steps and something or someone told me to go up the stairs and  I didn’t want to but it insisted I do so I went up. I remember three sets of doors I was allowed in the first two, it felt as if I was following two people. I tried to go in the third door but it was blocked by a a dark dense energy. I remember trying to penetrate the door twice but it pushed me out. The feeling was almost like I was a magnet and there was a second magnet in the door so when I pushed to go in mentally I was pushed back out. I was fascinated with being limited yet confused why i could not enter this door. I noticed  that the door formed into a scorpion like purple being and I remember telling it I’m not afraid of you but also getting the feeling that it is not about fear but about respecting the boundaries of sacred places I may not be ready to experience yet. It stung me on my right leg and I felt in the physical part of my body after the initial sting it sent three to four jolts in my legs.  I turned around and began moving away from the door/scorpion entity then the same entity(I think) that insisted I go up to the doors helped me go back down the stairs and told me I don’t belong here you do not know what you are doing open your eyes and return. I opened my eyes and I was back.

Only observe don’t be so quick to in force your will on the astral plane until you fully understand the effects of doing so.

Saw a labyrinth of flowers but I chose not stay inside  and I flew above it

The concert of peace and free energy

Breath is like the singing bowl  a steady consistent pattern and rhythm you will be able to feel a steady vibration also raising it as well

The first sound I remember hearing was a gong it struck me as weird being I was in Brooklyn and no gongs were near by to my knowledge but I felt as if I was in two places at once and now feeling the sound/vibration of the second place I’ve seemed to meditate into.

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